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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $995 | Backorder |
Description | CB1151, a 20-epi analogue of 1,25-dihydroxyvitamin D3, exhibits anti-tumor effects by inhibiting MCF-7 cell growth (IC50: 0.82 nM). |
In vitro | CB1151 (0-100 nM; 5 days) inhibits MCF-7 cell growth, as assessed by [3H]-thymidine incorporation (IC50: 0.82 nM). CB1151 (0-100 nM; 40 hours) activates the IP9-type VD response element (EC50: 1.2 nM) and shows a stronger correlation with inhibition of proliferation compared to DR3-type elements (EC50: 3.2 nM) in MCF-7 cells transfected with the CAT reporter [1]. CB1151 exhibits a functional dissociation constant (Kdf) of 3.6 nM, indicating the ligand concentration that provides 50% of the protease-resistant VDR fragment [2]. |
Molecular Weight | 446.672 |
Formula | C28H46O4 |
Cas No. | 182369-28-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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