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CCT241533 dihydrochloride

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CCT241533 dihydrochloride

Catalog No. T36704Cas No. 1962925-28-5

Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes.

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Pack Size	Price	Availability	Quantity
10 mg	$983	35 days

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Product Introduction

Bioactivity

Description	Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes. Caldwell et al (2011) Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J.Med.Chem. 54 580 PMID:21186793
Targets&IC50	Chk2:1.16 nM (Ki), Chk1:245 nM (IC50), Chk2:3 nM (IC50)
Alias	CCT 241533 dihydrochloride

Chemical Properties

Molecular Weight	515.41
Formula	C23H29Cl2FN4O4
Cas No.	1962925-28-5

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO: Soluble

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Keywords

CCT241533 DihydrochlorideCCT-241533 DihydrochlorideCCT-241533 dihydrochlorideCCT-241533CCT241533 dihydrochlorideCCT 241533 DihydrochlorideCCT 241533CCT241533