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CCT241533 hydrochloride

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Purity:97.13%

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COA HNMR HPLC

CCT241533 hydrochloride

Catalog No. T10718LCas No. 1431697-96-9

CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).

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Pack Size	Price	Availability
1 mg	$67	In Stock
2 mg	$97	In Stock
5 mg	$162	In Stock
10 mg	$253	In Stock
25 mg	$542	In Stock
50 mg	$896	In Stock
100 mg	$1,330	In Stock
500 mg	$2,680	In Stock
1 mL x 10 mM (in DMSO)	$179	In Stock

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Product Introduction

Bioactivity

Description

CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).

In vitro

CCT241533 hydrochloride inhibits CHK2 (IC50: 3 nM) and shows minimal cross-reactivity against a panel of kinases at 1 μM. X-ray crystallography confirms that CCT241533 binds to CHK2 in the ATP pocket. CCT241533 blocks CHK2 activity in human tumor cell lines in response to DNA damage. CCT241533 does not potentiate the cytotoxicity of a selection of genotoxic agents in several cell lines. However, CCT241533 significantly potentiates the cytotoxicity of two structurally distinct PARP inhibitors. Clear induction of the pS516 CHK2 signal is seen with a PARP inhibitor alone and this activation is abolished by CCT241533. In HT-29, HeLa, and MCF-7, the cytotoxicity of CCT241533 (GI50) is 1.7, 2.2, and 5.1 μM, respectively [1]. CCT241533 hydrochloride is a potent CHK2 inhibitor (IC50: 3 nM), with selectivity (63-fold) over CHK1(IC50: 190 nM) and low hERG inhibition (IC50: 22 μM) [2].

Chemical Properties

Molecular Weight	478.95
Formula	C23H28ClFN4O4
Cas No.	1431697-96-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (208.79 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0879 mL	10.4395 mL	20.8790 mL	104.3950 mL
5 mM	0.4176 mL	2.0879 mL	4.1758 mL	20.8790 mL
10 mM	0.2088 mL	1.0440 mL	2.0879 mL	10.4395 mL
20 mM	0.1044 mL	0.5220 mL	1.0440 mL	5.2198 mL
50 mM	0.0418 mL	0.2088 mL	0.4176 mL	2.0879 mL
100 mM	0.0209 mL	0.1044 mL	0.2088 mL	1.0440 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc