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CHK1-IN-3

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Purity:100%

ee:100%

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COA HPLC HNMR LCMS CSFC

CHK1-IN-3

Catalog No. T10791Cas No. 2097252-39-4

CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).

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Pack Size	Price	Availability
1 mg	$195	In Stock
2 mg	$293	In Stock
5 mg	$447	In Stock
10 mg	$659	In Stock
25 mg	$987	In Stock
50 mg	$1,380	In Stock
100 mg	$1,890	In Stock
1 mL x 10 mM (in DMSO)	$495	In Stock

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Product Introduction

Bioactivity

Description	CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).
In vitro	CHK1-IN-3 displays a low affinity for hERG (IC50 > 40 µM). CHK1-IN-3 effectively inhibits the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 µM)[1].
In vivo	In the Z-138 cell inoculated xenograft model, CHK1-IN-3 significantly suppresses the tumor growth as a single agent with bodyweight unaffected[1].

Chemical Properties

Molecular Weight	405.46
Formula	C20H23N9O
Cas No.	2097252-39-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (135.65 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4663 mL	12.3317 mL	24.6633 mL	123.3167 mL
5 mM	0.4933 mL	2.4663 mL	4.9327 mL	24.6633 mL
10 mM	0.2466 mL	1.2332 mL	2.4663 mL	12.3317 mL
20 mM	0.1233 mL	0.6166 mL	1.2332 mL	6.1658 mL
50 mM	0.0493 mL	0.2466 mL	0.4933 mL	2.4663 mL
100 mM	0.0247 mL	0.1233 mL	0.2466 mL	1.2332 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc