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CGRP (83-119), rat TFA

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Purity:100%

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COA LCMS

CGRP (83-119), rat TFA

Catalog No. TP1200

CGRP (83-119), rat TFA (Calcitonin Gene Related Peptide(83-119), rat TFA) is a 37 amino acid calcitonin family of neuropeptide, acts through calcitonin receptor-like receptor.

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Pack Size	Price	Availability
1 mg	$301	In Stock
5 mg	$737	In Stock
10 mg	$987	In Stock
25 mg	$1,530	In Stock
50 mg	$1,980	In Stock
100 mg	$2,790	In Stock

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Product Introduction

Bioactivity

Description	CGRP (83-119), rat TFA (Calcitonin Gene Related Peptide(83-119), rat TFA) is a 37 amino acid calcitonin family of neuropeptide, acts through calcitonin receptor-like receptor.
In vitro	Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA) belongs to the calcitonin family of neuropeptides which also includes adrenomedullin, amylin, calcitonin, intermedin and calcitonin receptor-stimulating peptide. Calcitonin Gene Related Peptide (CGRP) has two isoforms (αCGRP and βCGRP), and acts through calcitonin receptor-like receptor (CRLR)[1]. Calcitonin Gene Related Peptide (CGRP) plays a key role in migraine pathophysiology and is associated with activation of the trigeminovascular system. CGRP prossibly acts postjunctionally in these areas putatively involved in primary headaches[2].
In vivo	Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA) is a potent inducer of oedema in rat orofacial tissue. CGRP (100 μL; 8-33 pM) induces a rapidly developing (5-15?min) and long-lasting (6?h), dose-dependent oedema in the rat cheek. CGRP induces a smaller oedematogenic effect in the rat hind paw also blocked by the CGRP antagonist. CGRP (16 pM) potentiates the oedema induced by co-injected substance P (3.7 nM)[3].
Alias	Calcitonin Gene Related Peptide(83-119), rat TFA

Chemical Properties

Molecular Weight	3920.32
Formula	C162H262N50O52S2.C2HF3O2
Cas No.

Storage & Solubility Information

Storage

keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mg/mL (2.55 mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
5 mM	0.0510 mL	0.2551 mL	0.5102 mL	2.5508 mL
10 mM	0.0255 mL	0.1275 mL	0.2551 mL	1.2754 mL
20 mM	0.0128 mL	0.0638 mL	0.1275 mL	0.6377 mL
50 mM	0.0051 mL	0.0255 mL	0.0510 mL	0.2551 mL
100 mM	0.0026 mL	0.0128 mL	0.0255 mL	0.1275 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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