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Cixutumumab

🥰Excellent
Catalog No. T78279Cas No. 947687-12-9
Alias NSC742460, NSC 742460, LY3012217, LY 3012217, IMC-A12, IMCA12

Cixutumumab (IMC-A12) is a humanized IgG monoclonal antibody targeting the insulin-like growth factor 1 receptor (IGF1R). It has anticancer activity, inhibits ligand-dependent receptor activation and downstream signaling, and can be used in the study of non-small cell lung and prostate cancer.

Cixutumumab

Cixutumumab

🥰Excellent
Purity: 95%
Catalog No. T78279Alias NSC742460, NSC 742460, LY3012217, LY 3012217, IMC-A12, IMCA12Cas No. 947687-12-9
Cixutumumab (IMC-A12) is a humanized IgG monoclonal antibody targeting the insulin-like growth factor 1 receptor (IGF1R). It has anticancer activity, inhibits ligand-dependent receptor activation and downstream signaling, and can be used in the study of non-small cell lung and prostate cancer.
Pack SizePriceAvailabilityQuantity
1 mg$118In Stock
5 mg$328In Stock
10 mg$529In Stock
25 mg$843In Stock
50 mg$1,130In Stock
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Concentration:7.13 mg/mL
Purity:95%
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Product Introduction

Bioactivity
Description
Cixutumumab (IMC-A12) is a humanized IgG monoclonal antibody targeting the insulin-like growth factor 1 receptor (IGF1R). It has anticancer activity, inhibits ligand-dependent receptor activation and downstream signaling, and can be used in the study of non-small cell lung and prostate cancer.
In vitro
Cixutumumab showed significant growth inhibition of at least 50% in CHLA-9, TC-71 and Rh41 cell lines after 96 hours of treatment at concentrations ranging from 0.01 to 100 nM. [1]
In vivo
In an in vivo model of the Pediatric Preclinical Testing Program (PPTP), Cixutumumab, given to rats by intraperitoneal injection at a dose of 1 mg twice weekly for six weeks, showed potent antitumor effects and significantly inhibited the progression of solid tumors. [1]
AliasNSC742460, NSC 742460, LY3012217, LY 3012217, IMC-A12, IMCA12
Chemical Properties
Cas No.947687-12-9
Storage & Solubility Information
Storagestore at low temperature | store at -20°C | Shipping with blue ice.

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