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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $58 | In Stock |
Description | CLK8 is a selective CLOCK inhibitor that binds to and interferes with CLOCK activity, disrupts the interaction between CLOCK and BMAL1, and modulates circadian rhythm amplitude.CLK8 can be used to study circadian rhythm-related disorders. |
In vitro | CLK8 showed no toxicity to U2OS cells with a maximum concentration of 40 μM, maintaining cell viability above 80%. Similarly, CLK8 enhanced the amplitude of Bmal1-d Luc signal in U2OS and NIH 3T3 cells in a dose-dependent manner, and no circadian oscillations were observed in both cell lines[1]. |
In vivo | CLK8 was administered intraperitoneally to mice at a concentration of 25 mg/kg. The results indicated that CLK8 decreased the levels of CLOCK in the whole-cell lysate of mouse liver, while the levels of BMAL1 and CRY1 remained unchanged [1]. |
Molecular Weight | 498.53 |
Formula | C29H26N2O6 |
Cas No. | 898920-65-5 |
Storage | keep away from direct sunlight,keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (60.12 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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