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Compound 28

Name: Compound 28
Brand: TargetMol
SKU: T36307
Rating: 4.5 (1 reviews)

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Catalog No. T36307Cas No. 1062172-60-4

Compound 28 (mTOR inhibitor WYE-28) is a selective inhibitor of mTOR (IC50=0.08 nM). Also inhibits PI3Kα (IC50 6 nM).

Compound 28

😃Good

Catalog No. T36307Cas No. 1062172-60-4

Compound 28 (mTOR inhibitor WYE-28) is a selective inhibitor of mTOR (IC50=0.08 nM). Also inhibits PI3Kα (IC50 6 nM).

Pack Size	Price	Availability	Quantity
500 μg	Inquiry	35 days
1 mg	Inquiry	35 days

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Product Introduction

Bioactivity

Description

Compound 28 (mTOR inhibitor WYE-28) is a selective inhibitor of mTOR (IC50=0.08 nM). Also inhibits PI3Kα (IC50 6 nM).

Chemical Properties

Molecular Weight	586.653
Formula	C₃₀H₃₄N₈O₅
Cas No.	1062172-60-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 60 mg/mL (102.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7046 mL	8.5229 mL	17.0459 mL	85.2293 mL
5 mM	0.3409 mL	1.7046 mL	3.4092 mL	17.0459 mL
10 mM	0.1705 mL	0.8523 mL	1.7046 mL	8.5229 mL
20 mM	0.0852 mL	0.4261 mL	0.8523 mL	4.2615 mL
50 mM	0.0341 mL	0.1705 mL	0.3409 mL	1.7046 mL
100 mM	0.0170 mL	0.0852 mL	0.1705 mL	0.8523 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Compound 28