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7-Chloro-4-(piperazin-1-yl)quinoline

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Catalog No. Fr13587Cas No. 837-52-5

7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry, exhibiting diverse pharmacological profiles either alone or as a hybrid with other active pharmacophores. It is a potent sirtuin inhibitor, also inhibiting serotonin uptake (IC50 of 50 μM), and demonstrates antimalarial activity on D10 and K1 strains of P. falciparum with IC50 values of 1.18 μM and 0.97 μM, respectively [1].

7-Chloro-4-(piperazin-1-yl)quinoline

7-Chloro-4-(piperazin-1-yl)quinoline

🥰Excellent
Purity: 99.52%
Catalog No. Fr13587Cas No. 837-52-5
7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry, exhibiting diverse pharmacological profiles either alone or as a hybrid with other active pharmacophores. It is a potent sirtuin inhibitor, also inhibiting serotonin uptake (IC50 of 50 μM), and demonstrates antimalarial activity on D10 and K1 strains of P. falciparum with IC50 values of 1.18 μM and 0.97 μM, respectively [1].
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50 mg$37In Stock
100 mg$58In Stock
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Purity:99.52%
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Product Introduction

Bioactivity
Description
7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry, exhibiting diverse pharmacological profiles either alone or as a hybrid with other active pharmacophores. It is a potent sirtuin inhibitor, also inhibiting serotonin uptake (IC50 of 50 μM), and demonstrates antimalarial activity on D10 and K1 strains of P. falciparum with IC50 values of 1.18 μM and 0.97 μM, respectively [1].
Chemical Properties
Molecular Weight247.72
FormulaC13H14ClN3
Cas No.837-52-5
SmilesClC1=CC2=NC=CC(N3CCNCC3)=C2C=C1
Relative Density.1.257 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

7-Chloro-4-(piperazin-1-yl)quinolineCompound Fr13587
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