Powder: -20°C for 3 years | In solvent: -80°C for 1 year
COX-2/PI3K-IN-2 (compound 5f) has properties of anti-inflammatory and anti-cancer. COX-2/PI3K-IN-2 is a selective inhibitor of COX-2 (Ki = 3.02 nM) as well as a potent inhibitor of PI3K (IC 50 = 2.78 nM) [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,520.00 | |
50 mg | 10-14 weeks | $ 1,980.00 | |
100 mg | 10-14 weeks | $ 2,500.00 |
Description | COX-2/PI3K-IN-2 (compound 5f) has properties of anti-inflammatory and anti-cancer. COX-2/PI3K-IN-2 is a selective inhibitor of COX-2 (Ki = 3.02 nM) as well as a potent inhibitor of PI3K (IC 50 = 2.78 nM) [1]. |
In vitro | COX-2/PI3K-IN-2 (compound 5f), at concentrations ranging from 50-500 μg/mL over 72 hours, demonstrates significant antitumor effects on Breast cancer (MCF-7) cells, causing 40% cell death at a concentration of 1.65 μM. Additionally, at doses between 10-150 μg/mL, it exhibits antioxidant capabilities, showing H2O2 scavenging activity comparable to ascorbic acid and exhibiting stronger lysozyme inhibition (IC50=3.25 nM). These findings highlight the dual functional capacity of COX-2/PI3K-IN-2 in both anticancer activity and antioxidant properties. |
Molecular Weight | 311.34 |
Formula | C16H17N5O2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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COX-2/PI3K-IN-2 inhibitor inhibit