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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 10-14 weeks | |
50 mg | $1,980 | 10-14 weeks | |
100 mg | $2,500 | 10-14 weeks |
Description | COX-2/PI3K-IN-2 (compound 5f) possesses anti-inflammatory and anti-cancer properties, functioning as a selective inhibitor of COX-2 (Ki = 3.02 nM) and a potent inhibitor of PI3K (IC50 = 2.78 nM) [1]. |
In vitro | COX-2/PI3K-IN-2 (compound 5f), at concentrations of 50-500 μg/mL over 72 hours, demonstrates significant antitumor effects on Breast cancer (MCF-7) cells with 40% cell death at 1.65 μM. At 10-150 μg/mL, it also exhibits antioxidant capabilities, with H2O2 scavenging comparable to ascorbic acid and stronger lysozyme inhibition (IC50=3.25 nM), highlighting its dual functional capacity in anticancer activity and antioxidant properties. |
Molecular Weight | 311.34 |
Formula | C16H17N5O2 |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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