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COX-2-IN-31
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Catalog No. T78706
COX-2-IN-31 (compound 7b) is an orally active dual inhibitor targeting COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM), and also inhibits transmembrane hCA IX (Ki=48.9 nM) and hCA XII (Ki=5.8 nM), demonstrating anti-inflammatory and analgesic activity [1].
COX-2-IN-31
COX-2-IN-31
😃Good
Catalog No. T78706
COX-2-IN-31 (compound 7b) is an orally active dual inhibitor targeting COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM), and also inhibits transmembrane hCA IX (Ki=48.9 nM) and hCA XII (Ki=5.8 nM), demonstrating anti-inflammatory and analgesic activity [1].
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| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | COX-2-IN-31 (compound 7b) is an orally active dual inhibitor targeting COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM), and also inhibits transmembrane hCA IX (Ki=48.9 nM) and hCA XII (Ki=5.8 nM), demonstrating anti-inflammatory and analgesic activity [1]. |
| Targets&IC50 | COX-1:12.5 μM, COX-2:60 nM |
| In vitro | In the carbonic anhydrase inhibition assay, COX-2-IN-31 (compound 7b) effectively inhibited hCA IX and XII with Kᵢ values within the nanomolar range (48.9 nM and 5.8 nM) [1]. |
| In vivo | COX-2-IN-31 (compound 7b), administered orally at 10 mg/kg, demonstrated analgesic activity by significantly reducing writhing episodes in mice and decreasing paw edema height in carrageenan-induced rat paw edema tests while exhibiting gastric safety in albino male rats at this dose level [1]. |
| Molecular Weight | 400.41 |
| Formula | C17H16N6O4S |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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