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CPTH2 (hydrochloride) (357649-93-5 free base)
CPTH2 is an inhibitor of the HAT activity of Gcn5.
Catalog No. T22693Cas No. 2108899-91-6
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CPTH2 (hydrochloride) (357649-93-5 free base)
Catalog No. T22693Alias CPTH2 (hydrochloride)Cas No. 2108899-91-6
CPTH2 is an inhibitor of the HAT activity of Gcn5.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $243 | 35 days | |
| 10 mg | $320 | 35 days |
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Bioactivity
Chemical Properties
| Description | CPTH2 is an inhibitor of the HAT activity of Gcn5. |
| In vitro | In vitro: The previous study identified a novel molecule named CPTH2, which was selected based on its inhibitory effect on the growth of a gcn5Delta strain. This study indicated a specific chemical-genetic interaction between CPTH2 and HAT Gcn5p, suggesting that CPTH2 could inhibit the dependent functional network of Gcn5p. In addition, CPTH2 was found to be able to inhibit an in-vitro HAT reaction, which could be reversed by increasing the concentration of histone H3 [1]. |
| In vivo | In vivo: CPTH2 could decrease the acetylation of bulk histone H3 at the specific H3-AcK14 site [1]. |
| Alias | CPTH2 (hydrochloride) |
| Molecular Weight | 328.26 |
| Formula | C14H15Cl2N3S |
| Cas No. | 2108899-91-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: 16 mg/mL Ethanol: ≤5 mg/mL |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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