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dBRD9-A

Name: dBRD9-A
Brand: TargetMol
SKU: T35480
Price: 98 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T35480Cas No. 2170679-42-0

Alias dBRD9-A

Potent BRD9 degrader. Selectively binds BRD9 and elicits near complete degradation of BRD9 at nanomolar concentrations. Inhibits growth of synovial sarcoma cells in vitro and tumor progression in a synovial sarcoma xenograft mouse model.

dBRD9-A

Catalog No. T35480Alias dBRD9-ACas No. 2170679-42-0

Pack Size	Price	Availability	Quantity
5 mg	$987	35 days

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Product Introduction

Bioactivity

Description	Potent BRD9 degrader. Selectively binds BRD9 and elicits near complete degradation of BRD9 at nanomolar concentrations. Inhibits growth of synovial sarcoma cells in vitro and tumor progression in a synovial sarcoma xenograft mouse model.
Alias	dBRD9-A

Chemical Properties

Molecular Weight	779.88
Formula	C₄₂H₄₉N₇O₈
Cas No.	2170679-42-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

Ethanol: 7.8 mg/mL (10 mM)

DMSO: 77.99 mg/mL (100 mM)

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2822 mL	6.4112 mL	12.8225 mL	64.1124 mL
5 mM	0.2564 mL	1.2822 mL	2.5645 mL	12.8225 mL
10 mM	0.1282 mL	0.6411 mL	1.2822 mL	6.4112 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0641 mL	0.3206 mL	0.6411 mL	3.2056 mL
50 mM	0.0256 mL	0.1282 mL	0.2564 mL	1.2822 mL
100 mM	0.0128 mL	0.0641 mL	0.1282 mL	0.6411 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

dBRD9 AdBRD-9-AdBRD9A