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DC-BPi-11 hydrochloride
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Catalog No. T78142
DC-BPi-11 hydrochloride is a BPTF (bromodomain PHD finger transcription factor) inhibitor with an IC50 value of 698 nM, demonstrating significant anti-proliferative effects on leukemia cells [1].
DC-BPi-11 hydrochloride
DC-BPi-11 hydrochloride
😃Good
Catalog No. T78142
DC-BPi-11 hydrochloride is a BPTF (bromodomain PHD finger transcription factor) inhibitor with an IC50 value of 698 nM, demonstrating significant anti-proliferative effects on leukemia cells [1].
| Pack Size | Price | Availability | Quantity |
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| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | DC-BPi-11 hydrochloride is a BPTF (bromodomain PHD finger transcription factor) inhibitor with an IC50 value of 698 nM, demonstrating significant anti-proliferative effects on leukemia cells [1]. |
| In vitro | DC-BPi-11 hydrochloride at concentrations ranging from 0.1 nM to 1 μM over 24 hours inhibits BPTF in human leukemia MV-4-11 cells with an EC50 of 120 nM [1]. The same compound significantly suppresses the proliferation of these leukemia cells at 0.01 μM to 100 μM (IC50 = 0.89 μM) and reduces the expression of downstream oncogenes at concentrations between 2.5 and 20 μM over a 24-hour period [1]. Additionally, DC-BPi-11 hydrochloride dose-dependently decreases c-Myc protein levels at 0.6 to 50 μM after 24 hours [1]. This compound is deemed safe with minimal effects on normal cells [1]. |
| Molecular Weight | 433.95 |
| Formula | C20H24ClN5O2S |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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