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Demethylisoencecalin (6-Acetyl-5-hydroxy-2,2-dimethyl-2H-1-benzopyran) has anti-hyperglycemic activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | 103 € | In Stock | |
5 mg | 254 € | In Stock | |
10 mg | 372 € | In Stock | |
25 mg | 634 € | In Stock | |
50 mg | 901 € | In Stock | |
1 mL x 10 mM (in DMSO) | 266 € | In Stock |
Description | Demethylisoencecalin (6-Acetyl-5-hydroxy-2,2-dimethyl-2H-1-benzopyran) has anti-hyperglycemic activity. |
In vitro | Demethylisoencecalin (1) and caleins A (4) and C (5) (3.16–31.6 mg/kg, p.o.), the major components from an infusion of Calea ternifolia controlled postprandial glucose levels during an oral sucrose tolerance test (OSTT, 3 g/kg) in normal and nicotinamide/streptozotocin (NA/STZ, 40/100 mg/kg) hyperglicemic mice. The effects were comparable to those of acarbose (5 mg/kg). During the isolation of 1, 4, and 5, four additional metabolites not previously reported for the plant, were obtained, namely 6-acetyl-5-hydroxy-2-methyl-2-hydroxymethyl-2H-chromene (3), herniarin (6), scoparone (7), and 4′,7-dimethylapigenin (8). In addition, the structure of calein C (5) was confirmed by X-ray analysis. Pharmacological evaluation of the essential oil of the species (31.6–316.2 mg/kg, p.o.) provoked also an important decrement of blood glucose levels during an OSTT[1]. |
Alias | 6-Acetyl-5-hydroxy-2,2-dimethyl-2H-1-benzopyran |
Molecular Weight | 218.25 |
Formula | C13H14O3 |
Cas No. | 24672-84-2 |
Smiles | OC1=C2C(OC(C)(C)C=C2)=CC=C1C(C)=O |
Relative Density. | 1.154 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/ml (274.91 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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