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Dihydrorhodamine 123

Dihydrorhodamine 123 (DHR 123) is a fluorescent probe with excitation (λex=488 nm) and emission (λem=525 nm) wavelengths.

Catalog No. T18977Cas No. 109244-58-8

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Purity:97.75%

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COA HNMR HPLC

Dihydrorhodamine 123

Catalog No. T18977Cas No. 109244-58-8

Dihydrorhodamine 123 (DHR 123) is a fluorescent probe with excitation (λex=488 nm) and emission (λem=525 nm) wavelengths.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$39	In Stock
5 mg	$96	In Stock
10 mg	$143	In Stock
25 mg	$238	In Stock
50 mg	$358	In Stock

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Product Introduction

Bioactivity

Description	Dihydrorhodamine 123 (DHR 123) is a fluorescent probe with excitation (λex=488 nm) and emission (λem=525 nm) wavelengths.
In vitro	In the presence of 10 μM Dihydrorhodamine 123 (DHR 123), the stimulation of neutrophil NADPH oxidase with 50 nM phorbol 12-myristate 13-acetate (PMA) increases the rate of rhodamine generation. Similarly, induced HL60 cells exhibit a sustained fluorescence increase after the addition of 50 nM PMA in the presence of 10 μM DHR 123.
Alias	DHR 123

Chemical Properties

Molecular Weight	346.38
Formula	C₂₁H₁₈N₂O₃
Cas No.	109244-58-8

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 95 mg/mL (274.27 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8870 mL	14.4350 mL	28.8700 mL	144.3501 mL
5 mM	0.5774 mL	2.8870 mL	5.7740 mL	28.8700 mL
10 mM	0.2887 mL	1.4435 mL	2.8870 mL	14.4350 mL
20 mM	0.1444 mL	0.7218 mL	1.4435 mL	7.2175 mL
50 mM	0.0577 mL	0.2887 mL	0.5774 mL	2.8870 mL
100 mM	0.0289 mL	0.1444 mL	0.2887 mL	1.4435 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Dihydrorhodamine 123inhibitDihydrorhodamine-123Dihydrorhodamine123DHR123InhibitorDHR-123