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DLin-KC2-DMA

Name: DLin-KC2-DMA
Brand: TargetMol
SKU: T15139
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15139Cas No. 1190197-97-7

DLin-KC2-DMA is a cation that can be used for siRNA delivery and is also an ionizable lipid. DLinKC2-DMA can bind to LNP and enable siRNA-mediated GAPDH gene silencing.

DLin-KC2-DMA

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Purity: 97.74%

Catalog No. T15139Cas No. 1190197-97-7

DLin-KC2-DMA is a cation that can be used for siRNA delivery and is also an ionizable lipid. DLinKC2-DMA can bind to LNP and enable siRNA-mediated GAPDH gene silencing.

Pack Size	Price	Availability
2 mg	$33	In Stock
5 mg	$76	In Stock
10 mg	$123	In Stock
25 mg	$248	In Stock
50 mg	$353	In Stock
100 mg	$523	In Stock
200 mg	$747	In Stock

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Purity:97.74%

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COA HPLC HNMR

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Product Introduction

Bioactivity

Description	DLin-KC2-DMA is a cation that can be used for siRNA delivery and is also an ionizable lipid. DLinKC2-DMA can bind to LNP and enable siRNA-mediated GAPDH gene silencing.
In vitro	METHODS: Macrophages (MΦ) and dendritic cells (DC) were treated with DLinKC2-DMA (1,5μg/mL) to observe the effect of DLinKC2-DMA on siRNA-mediated gene silencing. GAPDH and control α-tubulin expression were evaluated using Western blot analysis and flow cytometry. RESULTS At a dose level of 5μg/ml, LNPs containing DLinKC2-DMA were again the most effective gene silencing agents. [1]
In vivo	METHODS: C57Bl6 mice were injected with DLinKC2-DMA-formulated LNP siRNA (5 mg/kg, tail vein injection) via the tail vein to study the in vivo gene silencing properties of DLinKC2-DMA-formulated LNP siRNA. RESULTS DLinKC2-DMA effectively silenced target genes in APcs in vivo. [1]

Chemical Properties

Molecular Weight	642.09
Formula	C₄₃H₇₉NO₂
Cas No.	1190197-97-7
Smiles	CCCCC\C=C/C\C=C/CCCCCCCCC1(CCCCCCCC\C=C/C\C=C/CCCCC)OCC(CCN(C)C)O1
Relative Density.	0.885 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

Ethanol: 50 mg/mL (77.87 mM), Sonication is recommended.

DMSO: 100 mg/mL (155.74 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5574 mL	7.7871 mL	15.5741 mL	77.8707 mL
5 mM	0.3115 mL	1.5574 mL	3.1148 mL	15.5741 mL
10 mM	0.1557 mL	0.7787 mL	1.5574 mL	7.7871 mL
20 mM	0.0779 mL	0.3894 mL	0.7787 mL	3.8935 mL
50 mM	0.0311 mL	0.1557 mL	0.3115 mL	1.5574 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0156 mL	0.0779 mL	0.1557 mL	0.7787 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorinhibitDLin-KC2-DMADLin-KC-2-DMADLinKC2DMADLin KC2 DMA