Docosahexaenoic Acid methyl ester (all cis-DHA methyl ester) is a methylated docosahexaenoic acid analog that can be inserted into membrane phospholipids without being oxidized or hydrolyzed.

After the application of methyl docosahexaenoate (DHA-Me), the incidence of sharp waves (SPW) relative to baseline appeared to decrease. In the absence of methyl docosahexaenoate (DHA), when bovine serum albumin (BSA) is exposed to a mixed functional oxidation system of Fe2+ and ascorbic acid (AsA), no new protein bands are produced. However, when BSA was incubated with DHA for only 24 hours, high molecular weight protein bands were observed. The incubation of BSA with 1.0 mM DHA resulted in a substantial increase in protein carbonyl content, while the addition of oxygen free radical scavenger resulted in a significant decrease in protein carbonyl content.