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E1R

Name: E1R
Brand: TargetMol
SKU: T10093L
Price: 48 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T10093LCas No. 1301211-78-8

E1R is a positive sigma-1 receptor (Sig1R PAM) allosteric modulator. It has a cognition-enhancing activity.

E1R

😃Good

Catalog No. T10093LCas No. 1301211-78-8

E1R is a positive sigma-1 receptor (Sig1R PAM) allosteric modulator. It has a cognition-enhancing activity.

Pack Size	Price	Availability
2 mg	$242	5 days
25 mg	$987	8-10 weeks
50 mg	$1,360	8-10 weeks
100 mg	$1,860	8-10 weeks
1 mL x 10 mM (in DMSO)	$253	5 days

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Product Introduction

Bioactivity

Description	E1R is a positive sigma-1 receptor (Sig1R PAM) allosteric modulator. It has a cognition-enhancing activity.
In vitro	E1R (10?μM) does not displace the radioligand. However, in Jurkat cells, it instead increases the specific binding of a non-selective radioligand ([3H]1,3-di(2-tolyl)guanidine) for the sigma receptor by 38%. The only target for E1R (inhibition or enhancement of radioligand binding exceeding 20%) is the sigma receptor.
In vivo	E1R (0.1-10?mg/kg; i.p. 60?min before the training session) treatment obviously improves cognitive function in a dose-related manner in mice. E1R demonstrates efficacy against scopolamine-induced cholinergic dysfunction in mice.

Chemical Properties

Molecular Weight	232.28
Formula	C₁₃H₁₆N₂O₂
Cas No.	1301211-78-8
Relative Density.	1.168 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 60 mg/mL (258.31 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3051 mL	21.5257 mL	43.0515 mL	215.2574 mL
5 mM	0.8610 mL	4.3051 mL	8.6103 mL	43.0515 mL
10 mM	0.4305 mL	2.1526 mL	4.3051 mL	21.5257 mL
20 mM	0.2153 mL	1.0763 mL	2.1526 mL	10.7629 mL
50 mM	0.0861 mL	0.4305 mL	0.8610 mL	4.3051 mL
100 mM	0.0431 mL	0.2153 mL	0.4305 mL	2.1526 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

E-1RE1R