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Eclazolast
🥰Excellent
Catalog No. T25360Cas No. 80263-73-6
Alias RHC-2871, RHC2871, RHC 2871, REV2871, REV 2871
Eclazolast (RHC 2871) is a lipophilic anti-allergic compound that inhibits mediator release in a mast cell model.Eclazolast inhibits extracellular secretion by affecting only the direct processes associated with Fc(epsilon)RI in the cell.The effect of Eclazolast is highly dependent on the concentration of antigen that triggers the cell.
Eclazolast
🥰Excellent
Purity: 100%
Catalog No. T25360Alias RHC-2871, RHC2871, RHC 2871, REV2871, REV 2871Cas No. 80263-73-6
Eclazolast (RHC 2871) is a lipophilic anti-allergic compound that inhibits mediator release in a mast cell model.Eclazolast inhibits extracellular secretion by affecting only the direct processes associated with Fc(epsilon)RI in the cell.The effect of Eclazolast is highly dependent on the concentration of antigen that triggers the cell.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $120 | In Stock | |
| 5 mg | $290 | In Stock | |
| 10 mg | $440 | In Stock | |
| 25 mg | $728 | In Stock | |
| 50 mg | $987 | In Stock | |
| 100 mg | $1,390 | In Stock | |
| 500 mg | $2,770 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $276 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Eclazolast (RHC 2871) is a lipophilic anti-allergic compound that inhibits mediator release in a mast cell model.Eclazolast inhibits extracellular secretion by affecting only the direct processes associated with Fc(epsilon)RI in the cell.The effect of Eclazolast is highly dependent on the concentration of antigen that triggers the cell. |
| Targets&IC50 | Rat:12 mg/kg(ED50), AIR:800 microM |
| In vitro | Eclazolast down-regulates IP3 levels. In contrast to lipophilic drugs, eclazolast does not affect artificial bilayers and erythrocyte membranes, and there is no effect on thapsigargin-induced Ca2+ influx. The effect of eclazolast was highly dependent on the antigen concentration with which the cells were triggered.[1] |
| In vivo | REV 2871 (CHBZ) was shown to be potent and orally effective inhibitors of passive cutaneous anaphylaxis (PCA) in the rat (ED50 = 12 mg/kg). In the guinea pig lung slice model, CHBZ inhibited AIR (IC50 = 800 microM).[2] |
| Alias | RHC-2871, RHC2871, RHC 2871, REV2871, REV 2871 |
| Molecular Weight | 269.68 |
| Formula | C12H12ClNO4 |
| Cas No. | 80263-73-6 |
| Smiles | C(OCCOCC)(=O)C=1OC=2C(N1)=CC(Cl)=CC2 |
| Relative Density. | 1.313g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 27.5 mg/mL (101.97 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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