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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $120 | In Stock | |
5 mg | $290 | In Stock | |
10 mg | $440 | In Stock | |
25 mg | $728 | In Stock | |
50 mg | $987 | In Stock | |
100 mg | $1,390 | In Stock | |
500 mg | $2,770 | In Stock | |
1 mL x 10 mM (in DMSO) | $276 | In Stock |
Description | Eclazolast (RHC 2871) is a lipophilic anti-allergic compound that inhibits mediator release in a mast cell model.Eclazolast inhibits extracellular secretion by affecting only the direct processes associated with Fc(epsilon)RI in the cell.The effect of Eclazolast is highly dependent on the concentration of antigen that triggers the cell. |
Targets&IC50 | Rat:12 mg/kg(ED50), AIR:800 microM |
In vitro | Eclazolast down-regulates IP3 levels. In contrast to lipophilic drugs, eclazolast does not affect artificial bilayers and erythrocyte membranes, and there is no effect on thapsigargin-induced Ca2+ influx. The effect of eclazolast was highly dependent on the antigen concentration with which the cells were triggered.[1] |
In vivo | REV 2871 (CHBZ) was shown to be potent and orally effective inhibitors of passive cutaneous anaphylaxis (PCA) in the rat (ED50 = 12 mg/kg). In the guinea pig lung slice model, CHBZ inhibited AIR (IC50 = 800 microM).[2] |
Alias | RHC2871, RHC-2871, REV2871, REV 2871, RHC 2871 |
Molecular Weight | 269.68 |
Formula | C12H12ClNO4 |
Cas No. | 80263-73-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 27.5 mg/mL (101.97 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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