Ecteinascidin 770 (ET-770) inhibits U373MG cells and is a 1,2,3, 4-tetrahydroisoquinoline alkaloid with strong anticancer activity.IC50 is 4.83 nM.

U373MG cells:4.83 nM

ET-770 (Ecteinascidin 770) significantly enhances the anoikis response in human lung cancer H23 and H460 cells by activating p53 protein. This activation leads to the down-regulation of anti-apoptotic myeloid cell leukemia sequence-1 (MCL1) and up-regulation of BCL2-associated X protein (BAX), while B-cell lymphoma-2 (BCL2) proteins remain largely unaffected. Additionally, ET-770 induces apoptosis in U373MG glioblastoma cells, with an IC50 value of 4.83 nM after a 72-hour treatment, as determined by the MTT assay. The IC50 values for HCT116, QG56, and DU145 human cell lines are found to be 0.6, 2.4, and 0.81 nM, respectively, showcasing its apoptotic effectiveness across various cell types in a dose-dependent manner.