Shopping Cart
- Remove All
Your shopping cart is currently empty
EHT 5372
EHT 5372 is a potent and selective inhibitor of DYRK’s family kinases. EHT 5372 shows IC 50 s of 0.22, 0.28, 10.8, 93.2, 22.8, 88.8, 59.0, 7.44, 221 nM for DYRK1A, DYRK1B, DYRK2， DYRK3， CLK1, CLK2, CLK4, GSK-3α, GSK-3β.
Catalog No. T61985Cas No. 1425945-63-6
Resource Download
EHT 5372
Catalog No. T61985Cas No. 1425945-63-6
EHT 5372 is a potent and selective inhibitor of DYRK’s family kinases. EHT 5372 shows IC 50 s of 0.22, 0.28, 10.8, 93.2, 22.8, 88.8, 59.0, 7.44, 221 nM for DYRK1A, DYRK1B, DYRK2， DYRK3， CLK1, CLK2, CLK4, GSK-3α, GSK-3β.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,620 | 8-10 weeks | |
| 50 mg | $2,110 | 8-10 weeks |
Bulk & Custom
Add to Cart
Questions
View MoreProduct Introduction
Bioactivity
Chemical Properties
| Description | EHT 5372 is a potent and selective inhibitor of DYRK’s family kinases. EHT 5372 shows IC 50 s of 0.22, 0.28, 10.8, 93.2, 22.8, 88.8, 59.0, 7.44, 221 nM for DYRK1A, DYRK1B, DYRK2， DYRK3， CLK1, CLK2, CLK4, GSK-3α, GSK-3β. |
| In vitro | EHT 5372 (0.1-10 μM; 24 hours) dose-dependently reduces pS396-Tau levels with an IC50 of 1.7 μM, maintaining cell viability over 87% in all conditions. It inhibits Tau phosphorylation by DYRK1A (0.01-1 μM) and reduces Aβ production with an IC50 of 1.06 μM. [1]. Cell Line: HEK293 cells. Concentration: 0.1, 0.5, 1, 5, 10 μM; Incubation Time: 24 hours. Results: Cell viability remained over 87%. Concentration: 0.01, 0.03, 0.1, 0.3, 1 μM. Result: Potently inhibited Tau phosphorylation at pS396 dose-dependently. |
| Molecular Weight | 404.27 |
| Formula | C17H11Cl2N5OS |
| Cas No. | 1425945-63-6 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy EHT 5372 | purchase EHT 5372 | EHT 5372 cost | order EHT 5372 | EHT 5372 chemical structure | EHT 5372 in vitro | EHT 5372 formula | EHT 5372 molecular weight
- TOP
Feedback
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.