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EN460

Name: EN460
Brand: TargetMol
SKU: T15218
Price: 76 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15218Cas No. 496807-64-8

Alias EN 460

EN460 is a selective inhibitor of Endoplasmic Reticulum Oxidase 1 (ERO1α), inhibiting ERO1L-mediated gene silencing and cell migration, and PDAC invasion.

EN460

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Purity: 99.23%

Catalog No. T15218Alias EN 460Cas No. 496807-64-8

EN460 is a selective inhibitor of Endoplasmic Reticulum Oxidase 1 (ERO1α), inhibiting ERO1L-mediated gene silencing and cell migration, and PDAC invasion.

Pack Size	Price	Availability	Quantity
2 mg	$76	In Stock

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Purity:99.23%

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COA HPLC

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	EN460 is a selective inhibitor of Endoplasmic Reticulum Oxidase 1 (ERO1α), inhibiting ERO1L-mediated gene silencing and cell migration, and PDAC invasion.
In vitro	EN460 selectively interacts with the reducing active form of ERO1α and prevents its reoxidation, IC50 = 1.9 μM. [1] EN460 inhibited the proliferation of PDAC cells in vitro. [2]
In vivo	In subcutaneous xenograft models, EN460 inhibited ERO1L, leading to a significant delay in tumor growth. [2]
Alias	EN 460

Chemical Properties

Molecular Weight	460.79
Formula	C₂₂H₁₂ClF₃N₂O₄
Cas No.	496807-64-8
Smiles	O=C(O)C1=CC(=CC=C1Cl)N2N=C(C(=CC=3OC(=CC3)C=4C=CC=CC4)C2=O)C(F)(F)F
Relative Density.	1.48 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 8 mg/mL (17.36 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1702 mL	10.8509 mL	21.7019 mL	108.5093 mL
5 mM	0.4340 mL	2.1702 mL	4.3404 mL	21.7019 mL
10 mM	0.2170 mL	1.0851 mL	2.1702 mL	10.8509 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

EN-460EN460