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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | Esomeprazole hemistrontium, also known as (S)-Omeprazole, is a potent and orally active proton pump inhibitor that effectively reduces acid secretion by inhibiting the H+, K+-ATPase in gastric parietal cells. This compound exhibits promising potential for research in symptomatic gastroesophageal reflux disease [1] [2] [3]. |
In vitro | Esomeprazole (25-100 μM; 20 hours; MDA-MB-468 cells) hemistrontium treatment suppresses growth of triple-negative breast cancer cell in vitro in a dose-dependent manner through increase in their intracellular acidification [1]. Cell Viability Assay [1] Cell Line: MDA-MB-468 cells Concentration: 25 μM, 50 μM, 75 μM, 100 μM Incubation Time: 20 hours Result: Suppressed growth of triple-negative breast cancer cell in vitro in a dose-dependent manner. |
In vivo | Esomeprazole administered via oral gavage at doses ranging from 30 to 300 mg/kg daily for 11 to 19 days significantly reduces lung fibrosis progression in C57BL/6J mice subjected to cotton smoke-induced lung injury. Additionally, this treatment lowers markers of inflammation and fibrosis in circulation. This study involved 8-week-old C57BL/6J mice weighing between 25-30 g. |
Molecular Weight | 776.44 |
Formula | C34H36N6O6S2Sr |
Cas No. | 914613-86-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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