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Ezabenlimab

🥰Excellent
Catalog No. T77003Cas No. 2249882-54-8
Alias BI-754091, BI754091

Ezabenlimab (BI-754091) is a humanized monoclonal antibody targeting programmed cell death protein-1 with antitumor activity that blocks the interaction of PD-1 with PD-L1 and PD-L2, inhibits tumor growth in vivo, and can be used to study advanced solid tumors.

Ezabenlimab

Ezabenlimab

🥰Excellent
Purity: 95%
Catalog No. T77003Alias BI-754091, BI754091Cas No. 2249882-54-8
Ezabenlimab (BI-754091) is a humanized monoclonal antibody targeting programmed cell death protein-1 with antitumor activity that blocks the interaction of PD-1 with PD-L1 and PD-L2, inhibits tumor growth in vivo, and can be used to study advanced solid tumors.
Pack SizePriceAvailabilityQuantity
1 mg$197In Stock
5 mg$516In Stock
10 mg$828In Stock
25 mg$1,230In Stock
50 mg$1,650In Stock
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Concentration:5.64 mg/mL
Purity:95%
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Product Introduction

Bioactivity
Description
Ezabenlimab (BI-754091) is a humanized monoclonal antibody targeting programmed cell death protein-1 with antitumor activity that blocks the interaction of PD-1 with PD-L1 and PD-L2, inhibits tumor growth in vivo, and can be used to study advanced solid tumors.
Targets&IC50
IFN-γ:0.9 nM (EC50), PD-1/PD-L1 (cynomolgus Monkeys):5.61 nM (IC90), PD-1/PD-L2 (cynomolgus Monkeys):7.54 nM (IC90), PD-1/PD-L1 (CHO cells):4.14 nM (IC90), PD-1/PD-L2 (CHO cells):3.98 nM (IC90)
In vitro
Ezabenlimab inhibited the interaction of PD-1 with PD-L1 and PD-L2 in CHO cells with IC90 of 4.14 nM and 3.98 nM, respectively; it also inhibited the interaction of PD-1 with PD-L1 and PD-L2 in cynomolgus Monkeys with IC90 of 5.61 nM and 7.54 nM, respectively.
In addition, Ezabenlimab was able to increase IFN-γ secretion in CD3-positive T cells after primary human antigen stimulation, with an EC50 of 0.9 nM.
In combination with BI 754111, 200 nM Ezabenlimab enhanced IFN-γ secretion. [1]
In vivo
In the hPD-1 knock-in mouse model, intraperitoneal injection of 0.3-30 mg/kg Ezabenlimab, single or twice a week or every 3 weeks, inhibited tumor progression and demonstrated significant antitumor activity. [1]
AliasBI-754091, BI754091
Chemical Properties
Cas No.2249882-54-8
Storage & Solubility Information
Storagestore at low temperature | store at -20°C | Shipping with blue ice.

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