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FGFR1 inhibitor-2
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Catalog No. T39992Cas No. 2410612-08-5
Alias FGFR1 inhibitor-2
FGFR1 inhibitor-2 (with an IC50 of 4.55 μM in MDA-MB-231 cells) is a potent inhibitor of FGFR1. It is specifically useful for studying metastatic triple-negative breast cancer.
FGFR1 inhibitor-2
😃Good
Catalog No. T39992Alias FGFR1 inhibitor-2Cas No. 2410612-08-5
FGFR1 inhibitor-2 (with an IC50 of 4.55 μM in MDA-MB-231 cells) is a potent inhibitor of FGFR1. It is specifically useful for studying metastatic triple-negative breast cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $970 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | FGFR1 inhibitor-2 (with an IC50 of 4.55 μM in MDA-MB-231 cells) is a potent inhibitor of FGFR1. It is specifically useful for studying metastatic triple-negative breast cancer. |
| In vitro | FGFR1 inhibitor-2, when applied at concentrations of 3 and 6 μM to MDA-MB-231 cells for a duration of 48 hours, effectively diminishes FGFR1 expression, as evidenced by Western Blot Analysis[1]. Additionally, a dose-dependent increase in the apoptotic index of MDA-MB-231 cells is observed, reaching a significant 10.6-fold elevation at a concentration of 5 μM, indicating a pronounced pro-apoptotic effect at this dosage[1]. |
| Alias | FGFR1 inhibitor-2 |
| Molecular Weight | 507.461 |
| Formula | C25H22F5N3O3 |
| Cas No. | 2410612-08-5 |
| Relative Density. | 1.350 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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