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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $78 | 35 days | |
25 mg | $158 | 35 days | |
50 mg | $250 | 35 days | |
100 mg | $460 | 35 days |
Description | Fluphenazine is a traditional antipsychotic compound that tightly binds the dopamine D2 receptor (Ki = 0.55 nM) and also reversibly inhibits calmodulin at micromolar concentrations. Fluphenazine-N-2-chloroethane is a derivative of fluphenazine that contains an alkylating chlorethylamine chain, which produces irreversible protein binding. It is a relatively selective, irreversible antagonist of D2 receptors both in vitro (IC50 = 100 nM) and in vivo, inactivating approximately 90% of D2 receptors in mice within 4 hours of treatment. Through this action, fluphenazine-B-2-chloroethane can be used to induce catalepsy in mice. It irreversibly inhibits calmodulin at higher doses (IC50 = 10 μM), which can sensitize cancer cells to TRAIL-induced apoptosis. |
Molecular Weight | 528.89 |
Formula | C22H27Cl3F3N3S |
Cas No. | 3892-78-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMSO: 10 mg/mL DMF: 10 mg/mL Ethanol: 1 mg/mL |
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