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FTY720 (S)-Phosphate

Name: FTY720 (S)-Phosphate
Brand: TargetMol
SKU: T15354
Price: 39 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T15354Cas No. 402616-26-6

Alias (S)-FTY720P, (S)-FTY720 phosphate

FTY720 (S)-Phosphate, an S1P receptor 1 (S1PR1) agonist, is utilized in research on acute inflammatory diseases, including acute lung injury.

FTY720 (S)-Phosphate

Catalog No. T15354Alias (S)-FTY720P, (S)-FTY720 phosphateCas No. 402616-26-6

FTY720 (S)-Phosphate, an S1P receptor 1 (S1PR1) agonist, is utilized in research on acute inflammatory diseases, including acute lung injury.

Pack Size	Price	Availability
25 mg	$1,710	8-10 weeks
50 mg	$2,230	8-10 weeks
100 mg	$3,100	8-10 weeks

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Product Introduction

Bioactivity

Description	FTY720 (S)-Phosphate, an S1P receptor 1 (S1PR1) agonist, is utilized in research on acute inflammatory diseases, including acute lung injury.
In vitro	FTY720 (S)-Phosphate (0.01-50 μM) also reduces β-arrestin recruitment to S1PR1. FTY720 (S)-Phosphate (Tys, 1 μM) maintains S1PR1 protein expression, enhances the human pulmonary artery endothelial cells barrier via S1PR1. But it shows no effect on inducing ubiquitination of S1PR1 [1].
In vivo	FTY720 (S)-Phosphate, administered intraperitoneally at a dose of 0.5 mg/kg, maintains S1PR1 expression in mouse lungs and offers protection against acute lung injury (ALI) induced by bleomycin. Additionally, it reduces leukocyte infiltration in the lung tissues of mice injured with bleomycin [1].
Alias	(S)-FTY720P, (S)-FTY720 phosphate

Chemical Properties

Molecular Weight	387.45
Formula	C₁₉H₃₄NO₅P
Cas No.	402616-26-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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