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FXR agonist 5

🥰Excellent
Catalog No. T75160Cas No. 2414008-05-0

FXR agonist 5 is an FXR agonist used in the study of liver diseases or diseases mediated by metabolic inflammation.

FXR agonist 5

FXR agonist 5

🥰Excellent
Purity: 99.74%
Catalog No. T75160Cas No. 2414008-05-0
FXR agonist 5 is an FXR agonist used in the study of liver diseases or diseases mediated by metabolic inflammation.
Pack SizePriceAvailabilityQuantity
1 mg$178 In Stock
5 mg$449 In Stock
10 mg$739 In Stock
25 mg$1,480 In Stock
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Purity:99.74%
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Product Introduction

Bioactivity
Description
FXR agonist 5 is an FXR agonist used in the study of liver diseases or diseases mediated by metabolic inflammation.
In vivo
FXR agonist 5 (3 mg/kg or 6 mg/kg) increases serum FGF-19 levels, decreases serum C4 levels, and improves one or more clinical symptoms of BAM. [1]
Chemical Properties
Molecular Weight683.88
FormulaC40H53N5O5
Cas No.2414008-05-0
SmilesCC=1C=C(C23CCC(CN(C(=O)[C@@H]4CC[C@@H](OC(=O)N5CC(O)C5)CC4)C6=CC(=CC=N6)C7=CN(C(C)(C)C)N=C7)(CC2)CC3)C=CC1OC
Storage & Solubility Information
Storagestore at low temperature | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (146.22 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.4622 mL7.3112 mL14.6224 mL73.1122 mL
5 mM0.2924 mL1.4622 mL2.9245 mL14.6224 mL
10 mM0.1462 mL0.7311 mL1.4622 mL7.3112 mL
20 mM0.0731 mL0.3656 mL0.7311 mL3.6556 mL
50 mM0.0292 mL0.1462 mL0.2924 mL1.4622 mL
100 mM0.0146 mL0.0731 mL0.1462 mL0.7311 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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