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Gelsevirine
🥰Excellent
Catalog No. TN1678Cas No. 38990-03-3
Gelsevirine, a novel STING-specific inhibitor, is an alkaloid from Gelsemium elegans with anxiolytic and antiproliferative activities that inhibits interferon and inflammatory cytokine induction in macrophages exposed to STING agonists, and attenuates STING-related inflammation in sepsis.
Gelsevirine
🥰Excellent
Purity: 97%
Catalog No. TN1678Cas No. 38990-03-3
Gelsevirine, a novel STING-specific inhibitor, is an alkaloid from Gelsemium elegans with anxiolytic and antiproliferative activities that inhibits interferon and inflammatory cytokine induction in macrophages exposed to STING agonists, and attenuates STING-related inflammation in sepsis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $243 | In Stock |
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CitedSelect Batch
Purity:97%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Gelsevirine, a novel STING-specific inhibitor, is an alkaloid from Gelsemium elegans with anxiolytic and antiproliferative activities that inhibits interferon and inflammatory cytokine induction in macrophages exposed to STING agonists, and attenuates STING-related inflammation in sepsis. |
| In vitro | Gelsevirine inhibits the dimerization and subsequent activation of STING induced by 2'3'-cGAMP; Gelsevirine also induces K48-linked ubiquitination and degradation of STING, which may be achieved through upregulation and recruitment of TRIM21[1]. |
| Molecular Weight | 352.43 |
| Formula | C21H24N2O3 |
| Cas No. | 38990-03-3 |
| Smiles | [H][C@]12CO[C@@H]3C[C@H]1[C@@]1(CN(C)[C@@]2([H])[C@]1([H])[C@@]31C(=O)N(OC)c2ccccc12)C=C |
| Relative Density. | 1.34 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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