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Gemcabene calcium

Name: Gemcabene calcium
Brand: TargetMol
SKU: T11386
Rating: 4.5 (1 reviews)

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Catalog No. T11386Cas No. 209789-08-2

Alias PD-72953 calcium

Gemcabene calcium , a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) andexerting anti-inflammatory activity, lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP).

Gemcabene calcium

😃Good

Catalog No. T11386Alias PD-72953 calciumCas No. 209789-08-2

Pack Size	Price	Availability	Quantity
2 mg	$83	5 days

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Gemcabene calcium , a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) andexerting anti-inflammatory activity, lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP).
In vitro	Gemcabene calcium (PD-72953 calcium) effectively reduces hepatic mRNA levels associated with inflammation (TNF-α, MCP-1, MIP-1β, CCR5, CCR2, NF-κB), fibrosis (TIMP-1, MMP-2), and fat production and regulation processes (ApoC-III, ACC1, ADH-4, Sulf-2).
Alias	PD-72953 calcium

Chemical Properties

Molecular Weight	344.505
Formula	C₁₆H₃₂CaO₅
Cas No.	209789-08-2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 10 mg/mL (29.37 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.9027 mL	14.5136 mL	29.0272 mL	145.1358 mL
5 mM	0.5805 mL	2.9027 mL	5.8054 mL	29.0272 mL
10 mM	0.2903 mL	1.4514 mL	2.9027 mL	14.5136 mL
20 mM	0.1451 mL	0.7257 mL	1.4514 mL	7.2568 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Gemcabene calcium