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Gemcabene (PD-72953) is a lipid-lowering agent with anti-inflammatory activity. Gemcabene lowers low-density lipoprotein cholesterol and triglycerides, raises high-density lipoprotein cholesterol, and decreases pro-inflammatory acute-phase protein, C-reactive protei
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $38 | In Stock | |
5 mg | $60 | In Stock | |
10 mg | $98 | In Stock | |
25 mg | $226 | In Stock | |
50 mg | $383 | In Stock | |
1 mL x 10 mM (in DMSO) | $54 | In Stock |
Description | Gemcabene (PD-72953) is a lipid-lowering agent with anti-inflammatory activity. Gemcabene lowers low-density lipoprotein cholesterol and triglycerides, raises high-density lipoprotein cholesterol, and decreases pro-inflammatory acute-phase protein, C-reactive protei |
In vitro | Gemcabene significantly downregulates hepatic mRNA markers of inflammation including TNF-α, MCP-1, MIP-1β, CCR5, CCR2, NF-κB, lipogenesis, fibrosis including TIMP-1 and MMP-2, and lipid modulation including ApoC-III, ACC1, ADH-4 and Sulf-2[2]. |
Alias | PD-72953 |
Molecular Weight | 302.41 |
Formula | C16H30O5 |
Cas No. | 183293-82-5 |
Smiles | CC(C)(CCCCOCCCCC(C)(C)C(O)=O)C(O)=O |
Relative Density. | 1.048 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 95 mg/mL (314.14 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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