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Glycerophospho-N-Arachidonoyl Ethanolamine

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Catalog No. T37530Cas No. 201738-25-2

N-Acylated ethanolamines (NAE) are naturally-occurring lipids that have diverse bioactivities. The different types of NAE can be derived from glycerophospho-linked precursors by the activity of glycerophosphodiesterase 1 (GDE1). Glycerophospho-N-arachidonoyl ethanolamine is the precursor of arachidonoyl ethanolamide (AEA), also known as anandamide. AEA is an endogenous cannabinoid neurotransmitter that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It inhibits the specific binding of [3H]-HU-243 to synaptosomal membranes with a Ki value of 52 nM, compared to 46 nM for δ9-THC.

Glycerophospho-N-Arachidonoyl Ethanolamine

Glycerophospho-N-Arachidonoyl Ethanolamine

😃Good
Catalog No. T37530Cas No. 201738-25-2
N-Acylated ethanolamines (NAE) are naturally-occurring lipids that have diverse bioactivities. The different types of NAE can be derived from glycerophospho-linked precursors by the activity of glycerophosphodiesterase 1 (GDE1). Glycerophospho-N-arachidonoyl ethanolamine is the precursor of arachidonoyl ethanolamide (AEA), also known as anandamide. AEA is an endogenous cannabinoid neurotransmitter that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It inhibits the specific binding of [3H]-HU-243 to synaptosomal membranes with a Ki value of 52 nM, compared to 46 nM for δ9-THC.
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1 mg$210 35 days
5 mg$923 35 days
10 mg$1,620 35 days
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Product Introduction

Bioactivity
Description
N-Acylated ethanolamines (NAE) are naturally-occurring lipids that have diverse bioactivities. The different types of NAE can be derived from glycerophospho-linked precursors by the activity of glycerophosphodiesterase 1 (GDE1). Glycerophospho-N-arachidonoyl ethanolamine is the precursor of arachidonoyl ethanolamide (AEA), also known as anandamide. AEA is an endogenous cannabinoid neurotransmitter that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It inhibits the specific binding of [3H]-HU-243 to synaptosomal membranes with a Ki value of 52 nM, compared to 46 nM for δ9-THC.
Chemical Properties
Molecular Weight501.601
FormulaC25H44NO7P
Cas No.201738-25-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 20 mg/mL (39.87 mM), Sonication is recommended.
DMF: 20 mg/mL (39.87 mM), Sonication is recommended.
PBS (pH 7.2): 10 mg/mL (19.94 mM), Sonication is recommended.
Solution Preparation Table
PBS (pH 7.2)/DMSO/DMF
1mg5mg10mg50mg
1 mM1.9936 mL9.9681 mL19.9362 mL99.6808 mL
5 mM0.3987 mL1.9936 mL3.9872 mL19.9362 mL
10 mM0.1994 mL0.9968 mL1.9936 mL9.9681 mL
DMSO/DMF
1mg5mg10mg50mg
20 mM0.0997 mL0.4984 mL0.9968 mL4.9840 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

GlycerophosphoNArachidonoyl EthanolamineGlycerophospho N Arachidonoyl EthanolamineGlycerophospho-N-Arachidonoyl Ethanolamine
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