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GNE-502, an orally active and potent estrogen receptor (ER) degrader, is specifically designed for breast cancer research.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $623 | Backorder |
Description | GNE-502, an orally active and potent estrogen receptor (ER) degrader, is specifically designed for breast cancer research. |
In vivo | GNE-502, administered orally at doses of 10 and 100 mg/kg, demonstrates adequate oral bioavailability for evaluation in a WT MCF7 tumor xenograft mouse model. It exhibits dose-dependent tumor growth inhibition at 10 and 30 mg/kg and achieves tumor stasis at 100 mg/kg, indicative of its potential efficacy in cancer therapy. Dosage and administration details for pharmacokinetic analysis confirm its sufficient oral exposure for effectiveness in the specified model. |
Molecular Weight | 471.59 |
Formula | C25H30FN3O3S |
Cas No. | 1953134-16-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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