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HDAC-IN-46

Catalog No. T62514Cas No. 2562386-85-8

HDAC-IN-46 (compound 12c) is a potent inhibitor of HDAC, targeting HDAC1 (IC50: 0.21 μM) and HDAC6 (IC50: 0.021 μM). It upregulates p-p38, downregulates Bcl-xL and cyclin D1 in MDA-MB-231 cells, blocks the cell cycle in the G2 phase, and induces apoptosis, making it useful for triple negative breast cancer (TNBC) studies.

HDAC-IN-46

HDAC-IN-46

Catalog No. T62514Cas No. 2562386-85-8
HDAC-IN-46 (compound 12c) is a potent inhibitor of HDAC, targeting HDAC1 (IC50: 0.21 μM) and HDAC6 (IC50: 0.021 μM). It upregulates p-p38, downregulates Bcl-xL and cyclin D1 in MDA-MB-231 cells, blocks the cell cycle in the G2 phase, and induces apoptosis, making it useful for triple negative breast cancer (TNBC) studies.
Pack SizePriceAvailabilityQuantity
25 mg$2,1408-10 weeks
50 mg$2,7858-10 weeks
100 mg$3,5208-10 weeks
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Product Introduction

Bioactivity
Description
HDAC-IN-46 (compound 12c) is a potent inhibitor of HDAC, targeting HDAC1 (IC50: 0.21 μM) and HDAC6 (IC50: 0.021 μM). It upregulates p-p38, downregulates Bcl-xL and cyclin D1 in MDA-MB-231 cells, blocks the cell cycle in the G2 phase, and induces apoptosis, making it useful for triple negative breast cancer (TNBC) studies.
Chemical Properties
Molecular Weight438.53
FormulaC22H30N8O2
Cas No.2562386-85-8
Storage & Solubility Information
StorageShipping with blue ice.

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