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HMR 1556

🥰Excellent
Catalog No. T15487Cas No. 223749-46-0

HMR 1556 is a chromanol derivative and is an IKs blocker (IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively).

HMR 1556

HMR 1556

🥰Excellent
Catalog No. T15487Cas No. 223749-46-0
HMR 1556 is a chromanol derivative and is an IKs blocker (IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively).
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Product Introduction

Bioactivity
Description
HMR 1556 is a chromanol derivative and is an IKs blocker (IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively).
Targets&IC50
IKs (canine left ventricular myocytes):10.5 nM, IKs (guinea pig left ventricular myocytes):34 nM
In vitro
HMR 1556 suppresses Ito, ICa, L, and IKr (IC50s of 33.9 μM, 27.5 μM, 12.6 μM in canine left ventricular myocytes, respectively)[1].
Chemical Properties
Molecular Weight411.44
FormulaC17H24F3NO5S
Cas No.223749-46-0
Relative Density.1.35 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

HMR1556HMR 1556HMR-1556
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