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Description | HO-PEG10-CH2COOH is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands and crucial for forming PROTAC molecules [that enable selective protein degradation via the ubiquitin-proteasome system within cells]. |
In vitro | PROTACs consist of two distinct ligands linked together: one ligand targets an E3 ubiquitin ligase, while the other targets the desired protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs facilitate the selective degradation of target proteins[1]. |
Molecular Weight | 516.58 |
Formula | C22H44O13 |
Cas No. | 2250056-53-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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