ho-peg-10-ch2cooh

NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).

HO-PEG10-CH2COOH is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands and crucial for forming PROTAC molecules [that enable selective protein degradation via the ubiquitin-proteasome system within cells].

2-Caren-10-ol is a useful organic compound for research related to life sciences and the catalog number is T124382.

SARS-CoV-2-IN-10 is a powerful and non-toxic inhibitor of SARS-CoV-2 3CL protease, with IC50 and EC50 values of 0.13 nM and 1.03 nM, respectively. The SARS-CoV-2 3C-like protease (3CLpro) is critical for viral replication and serves as an ideal target for intervention. By targeting the SARS-CoV-2 3CL protease, SARS-CoV-2-IN-10 has the potential to facilitate the development of effective antiviral drugs specific to SARS-CoV-2.

SARS-CoV-2 3CLpro-IN-10(5d) is a potent inhibitor of the SARS-CoV-2 3CL protease with an IC50 value of 190 nM and demonstrates broad-spectrum antiviral activity, exhibiting IC50 values of 790 nM for SARS-CoV-1 and 70 nM for MERS-CoV.

(E/Z)-10-Hydroxy-2-decenoic acid is a useful organic compound for research related to life sciences. The catalog number is T124254 and the CAS number is 765-01-5.

HO-PEG-mal (MW 3400) is a PEG-based linker for PROTACs, joining two essential ligands necessary for forming PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

20)abeotaxa-4(20),11-dien-10-one'>2alpha,7beta,13alpha-Triacetoxy-5alpha-cinnamoyloxy-9beta-hydroxy-2(3->20)abeotaxa-4(20),11-dien-10-one is a natural product for research related to life sciences. The catalog number is TN2840 and the CAS number is 322471-42-1.

SARS-CoV-2 Mpro-IN-10 (27h) is a potent inhibitor of the Mpro enzyme, with IC50 and EC50 values of 10.9 nM and 43.6 nM, respectively. It is used in research on the SARS-CoV-2 virus [1].

VEGFR-2-IN-10 has enhanced antiangiogenic potency against VEGFR2 phosphorylation induced by VEGF with an IC50 value of 0.7 μM and no cytotoxic effects.

Aristola-1(10),8-dien-2-one (Catalog No. TN3442, CAS No. 22391-34-0) is a natural product that can be used as a reference standard.

8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol, a chemical component of essential oils from Telekia speciosa, exhibits significant antiproliferative activity against human cancer cell lines in vitro.

(S,R,S)-AHPC-(C3-PEG)2-C6-Cl is a small molecule HaloPROTAC incorporating the (S,R,S)-AHPC-based VHL ligand and a 2-unit PEG linker, capable of inducing degradation of GFP-HaloTag7 in cell-based assays [1].

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a chemically synthesized E3 ligase ligand-linker conjugate, incorporating the cereblon ligand from Pomalidomide and a linker used in PROTAC technology. It facilitates targeted protein degradation by modulating E3 ligase activity, thereby enabling the selective elimination of specific proteins of interest.

11R,12-Dihydroxyspirovetiv-1(10)-en-2-one is a natural product for research related to life sciences. The catalog number is TN2593 and the CAS number is 62574-30-5.

Mal-PEG-COOH, mw.2000 is a useful organic compound for research related to life sciences and the catalog number is T64802.

COX-2-IN-10 is a potent COX-2 inhibitor that exhibits inhibitory effects on the production of IL-6, TNF-α, and IL-1β, and inhibits PGE2 production in a concentration-dependent manner with an IC50 value of 2.54 μM. Additionally, COX-2-IN-10 inhibits the expression of iNOS and COX-2 at both mRNA and protein levels.

HO-PEG-CH2COOH (MW 5000), a polyethylene glycol (PEG)-based PROTAC linker, serves as a valuable component in the synthesis of PROTACs[1].

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker, incorporating a cereblon ligand based on Thalidomide and a 3-unit PEG linker, specifically designed for PROTAC technology applications.

HO-PEG-amine (MW 1000) is a PEG-based linker used in PROTACs to connect two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system in cells.

Nrf2 HO-1 activator 2 (compound 13m), a difluoro-substituted derivative, is a highly potent activator of Nrf2 HO-1 with substantial neuroprotective and antioxidant properties. It functions by activating the Nrf2 HO-1 pathway through the phosphorylation of ERK1 2, JNK, or Akt in PC12 cells and is useful in investigating Parkinson's disease (PD) [1].

HO-PEG-CH2COOH (MW 3400) is a PEGylated PROTAC linker with a molecular weight of 3400, serving as a PEG-based building block for PROTAC synthesis[1].

HO-PEG-amine (MW 2000) is a PEG-based linker essential for constructing PROTAC molecules. It connects two critical ligands, facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

HO-PEG-amine (MW 3400) is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

3,11,12-Trihydroxyspirovetiv-1(10)-en-2-one is a natural product for research related to life sciences. The catalog number is TN5344 and the CAS number is 220328-04-1.

3,11,12-Trihydroxyspirovetiv-1(10)-en-2-one is a natural product from Murraya exotica L

[(1(10)E,2R,4R)]-2-Methoxy-8,12-epoxygermacra-1(10),7,11-trien-6-one, a sesquiterpene from turmeric, is also known as (1(10)E,2R*,4R*)-2-Methoxy-8,12-epoxygermacra-1(10),7,11-trien-6-one.

Metal complex, bioreagent

Ammonium, diethylmethyl(2-(10-phenothiazinyl)ethyl)-, iodide is a biaoctive chemical.

2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one is a natural product

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate that combines a Thalidomide-based cereblon ligand and a linker, commonly utilized in PROTAC technology. This compound serves as a connector between the target protein and the E3 ligase, facilitating targeted protein degradation.

DSPE-PEG-2-Aminoethyl-alpha-mannopyranoside (MW 2000) is a polyethylene glycol (PEG) derived linker used in the synthesis of proteolysis targeting chimeras (PROTACs) [1].

3-(2'-Deoxyribofuranosyl)pyrimido(1,2-a)purin-10(3H)-one is a malondialdehyde-deoxyguanosine adduct.

Acridan-9-carboxylic acid, 10-methyl-, 2-(diethylamino)ethyl ester, hydrochloride is a biochemical.

HO-PEG-amine (MW 5000) is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

HO-PEG-mal (MW 5000) is a PEG-based linker for PROTACs that connects two essential ligands necessary for forming PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system in cells.

HO-PEG-amine (MW 10000), a polyethylene glycol (PEG) derivative, is utilized as a PROTAC linker for the synthesis of PROTACs[1].

2-Carene-10-al is a principal constituent of the essential oil extracted from Cuminum cyminum L. [1].

8-Hydroxy-9,10-diisobutyryloxy-thymol, a potent terpenoid found in Inula sericophylla [1], exhibits significant bioactivity.

11S,12-Dihydroxyspirovetiv-1(10)-en-2-one is a natural product for research related to life sciences. The catalog number is TN2594 and the CAS number is 62623-86-3.

1(10)-Aristolen-2-one has antifungal activity.