Shopping Cart
- Remove All
Your shopping cart is currently empty
HSR6071
😃Good
Catalog No. T11581Cas No. 111374-21-1
HSR6071 is a novel orally active and potent anti-allergic agent with inhibitory effects on passive cutaneous anaphylaxis. HSR6071 showed anti-asthmatic activity in a rat model of experimental asthma.
HSR6071
😃Good
Purity: 99.59%
Catalog No. T11581Cas No. 111374-21-1
HSR6071 is a novel orally active and potent anti-allergic agent with inhibitory effects on passive cutaneous anaphylaxis. HSR6071 showed anti-asthmatic activity in a rat model of experimental asthma.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $169 | 5 days | |
| 5 mg | $291 | 5 days | |
| 10 mg | $465 | 5 days | |
| 50 mg | $1,610 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
Bulk & Custom
Add to Cart
Questions
View MoreSelect Batch
Purity:99.59%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | HSR6071 is a novel orally active and potent anti-allergic agent with inhibitory effects on passive cutaneous anaphylaxis. HSR6071 showed anti-asthmatic activity in a rat model of experimental asthma. |
| In vivo | HSR-6071 (0.01-0.1 mg/kg; i.v.) inhibits experimental asthma induced by IgE antibody in rats in a dose-dependent manner. Additionally, HSR-6071 (0.3, 1.3 mg/kg; i.v.) prevents bronchoconstriction mediated by IgE or IgG antibody in guinea pigs. The compound inhibits cyclic AMP phosphodiesterase activity and induces relaxation of the guinea pig isolated trachea[1].With an IC50 of 0.46 nM, HSR-6071 inhibits IgE-mediated histamine release. Its effectiveness is observed not only through intravenous (i.v.) administration but also through oral (p.o.) administration in IgE-mediated passive cutaneous anaphylaxis (PCA) in rats. The most potent inhibition with HSR-6071 occurs when administered orally 5 minutes before the antigen challenge, indicating rapid absorption through the gastrointestinal tract[1]. |
| Molecular Weight | 260.26 |
| Formula | C10H12N8O |
| Cas No. | 111374-21-1 |
| Smiles | O=C(Nc1nnn[nH]1)c1cncc(n1)N1CCCC1 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 20 mg/mL (76.85 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy HSR6071 | purchase HSR6071 | HSR6071 cost | order HSR6071 | HSR6071 chemical structure | HSR6071 in vivo | HSR6071 formula | HSR6071 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.