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HSR6071

Name: HSR6071
Brand: TargetMol
SKU: T11581
Price: 30 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T11581Cas No. 111374-21-1

HSR6071 is a novel orally active and potent anti-allergic agent with inhibitory effects on passive cutaneous anaphylaxis. HSR6071 showed anti-asthmatic activity in a rat model of experimental asthma.

HSR6071

Purity: 99.59%

Catalog No. T11581Cas No. 111374-21-1

HSR6071 is a novel orally active and potent anti-allergic agent with inhibitory effects on passive cutaneous anaphylaxis. HSR6071 showed anti-asthmatic activity in a rat model of experimental asthma.

Pack Size	Price	Availability
2 mg	$169	5 days
5 mg	$291	5 days
10 mg	$465	5 days
50 mg	$1,610	6-8 weeks
100 mg	$2,500	6-8 weeks

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Purity:99.59%

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COA HNMR LCMS

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Product Introduction

Bioactivity

Description

HSR6071 is a novel orally active and potent anti-allergic agent with inhibitory effects on passive cutaneous anaphylaxis. HSR6071 showed anti-asthmatic activity in a rat model of experimental asthma.

In vivo

HSR-6071 (0.01-0.1 mg/kg; i.v.) inhibits experimental asthma induced by IgE antibody in rats in a dose-dependent manner. Additionally, HSR-6071 (0.3, 1.3 mg/kg; i.v.) prevents bronchoconstriction mediated by IgE or IgG antibody in guinea pigs. The compound inhibits cyclic AMP phosphodiesterase activity and induces relaxation of the guinea pig isolated trachea[1].With an IC50 of 0.46 nM, HSR-6071 inhibits IgE-mediated histamine release. Its effectiveness is observed not only through intravenous (i.v.) administration but also through oral (p.o.) administration in IgE-mediated passive cutaneous anaphylaxis (PCA) in rats. The most potent inhibition with HSR-6071 occurs when administered orally 5 minutes before the antigen challenge, indicating rapid absorption through the gastrointestinal tract[1].

Chemical Properties

Molecular Weight	260.26
Formula	C₁₀H₁₂N₈O
Cas No.	111374-21-1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 20 mg/mL (76.85 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.8423 mL	19.2116 mL	38.4231 mL	192.1156 mL
5 mM	0.7685 mL	3.8423 mL	7.6846 mL	38.4231 mL
10 mM	0.3842 mL	1.9212 mL	3.8423 mL	19.2116 mL
20 mM	0.1921 mL	0.9606 mL	1.9212 mL	9.6058 mL
50 mM	0.0768 mL	0.3842 mL	0.7685 mL	3.8423 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

HSR 6071HSR6071HSR-6071