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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $9,078 | 6-8 weeks | |
50 mg | Inquiry | 6-8 weeks | |
100 mg | Inquiry | 6-8 weeks |
Description | IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1). |
Targets&IC50 | BRPF1:14 nM , TRIM24:(kd)31 nM , TRIM24:8 nM |
In vitro | IACS-9571 is a selective dual TRIM24/BRPF1 inhibitor (Kd = 1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 does not interact with the BET sub-family of bromodomains, displaying greater than 7,700-fold selectivity versus BRD4(1, 2) relative to TRIM24.IACS-9571 shows excellent cellular potency with EC50 of 50 nM.?IACS-9571 (1 μM) has potent activities against a panel of 32 bromodomains. |
Alias | ASIS-P040 |
Molecular Weight | 642.76 |
Formula | C32H42N4O8S |
Cas No. | 1800477-30-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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