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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | Inquiry | Backorder | |
5 mg | Inquiry | Backorder |
Description | Inclisiran (ALN-PCSsc) is a double-stranded small interfering RNA (siRNA) compound that effectively suppresses PCSK-9 transcription. It proves promising in the investigation of hyperlipidemia and cardiovascular disease (CVD). |
In vitro | Inclisiran, a double-stranded small RNA molecule, functions by inhibiting the transcription of proprotein convertase subtilisin kexin 9 (PCSK-9). This action decreases PCSK-9 levels in hepatocytes, which in turn enhances the expression of low-density lipoprotein (LDL) receptors on hepatocyte membranes. As a result, circulating levels of LDL cholesterol (LDL-C) are reduced[1]. |
Alias | ALN-PCSsc |
Cas No. | 1639324-58-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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