JAMI1001A is a positive allosteric modulator of the AMPA receptor, effectively modulating the deactivation and desensitization of both [flip] and [flop] receptor isoforms.

JAMI1001A attaches to the solvent-accessible allosteric pocket located at the interface between the dimers of the AMPA receptor ligand-binding core. It effectively inhibits channel desensitization and decelerates deactivation in both flip and flop isoforms of the AMPA receptor GluA2[1]. A kinetic model indicates that JAMI1001A independently regulates the protein rearrangements required for channel desensitization and recovery from this state, as well as those needed for channel deactivation (closed-cleft stability or channel gating)[1].