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JAMI1001A
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Catalog No. T38392Cas No. 1001019-46-0
JAMI1001A is a positive allosteric modulator of the AMPA receptor, effectively modulating the deactivation and desensitization of both [flip] and [flop] receptor isoforms.
JAMI1001A
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Catalog No. T38392Cas No. 1001019-46-0
JAMI1001A is a positive allosteric modulator of the AMPA receptor, effectively modulating the deactivation and desensitization of both [flip] and [flop] receptor isoforms.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $970 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | JAMI1001A is a positive allosteric modulator of the AMPA receptor, effectively modulating the deactivation and desensitization of both [flip] and [flop] receptor isoforms. |
| In vitro | JAMI1001A attaches to the solvent-accessible allosteric pocket located at the interface between the dimers of the AMPA receptor ligand-binding core. It effectively inhibits channel desensitization and decelerates deactivation in both flip and flop isoforms of the AMPA receptor GluA2[1]. A kinetic model indicates that JAMI1001A independently regulates the protein rearrangements required for channel desensitization and recovery from this state, as well as those needed for channel deactivation (closed-cleft stability or channel gating)[1]. |
| Molecular Weight | 402.39 |
| Formula | C16H17F3N4O3S |
| Cas No. | 1001019-46-0 |
| Relative Density. | 1.66 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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