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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $970 | Backorder |
Description | JAMI1001A is a positive allosteric modulator of the AMPA receptor, effectively modulating the deactivation and desensitization of both [flip] and [flop] receptor isoforms. |
In vitro | JAMI1001A attaches to the solvent-accessible allosteric pocket located at the interface between the dimers of the AMPA receptor ligand-binding core. It effectively inhibits channel desensitization and decelerates deactivation in both flip and flop isoforms of the AMPA receptor GluA2[1]. A kinetic model indicates that JAMI1001A independently regulates the protein rearrangements required for channel desensitization and recovery from this state, as well as those needed for channel deactivation (closed-cleft stability or channel gating)[1]. |
Molecular Weight | 402.39 |
Formula | C16H17F3N4O3S |
Cas No. | 1001019-46-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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