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K1-70
🥰Excellent
Catalog No. T77360
Alias Anti-TSHR Antibody (K1-70)
K1-70 is a humanized antibody targeting TSHR, used in the study of autoimmune diseases and endocrine disorders.
K1-70
K1-70
🥰Excellent
Catalog No. T77360Alias Anti-TSHR Antibody (K1-70)
K1-70 is a humanized antibody targeting TSHR, used in the study of autoimmune diseases and endocrine disorders.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $125 | In Stock | |
| 5 mg | $398 | In Stock | |
| 10 mg | $639 | In Stock | |
| 25 mg | $1,086 | In Stock | |
| 50 mg | $1,629 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | K1-70 is a humanized antibody targeting TSHR, used in the study of autoimmune diseases and endocrine disorders. |
| Targets&IC50 | TSHR (human):851.2 ng/mL (EC50) |
| In vitro | K1-70 is the most potent inhibitor of TSH binding to the receptor, producing 97% inhibition as low as 0.1 μg/mL. [1] K1-70 (0.1 μg/ ml-0.5 μg/mL) inhibited the cyclic AMP stimulating activity of M22 IgG (3 ng/mL) in a dose-dependent manner in CHO cells expressing TSHR. [2] |
| In vivo | K1-70 (100-200 μg) caused serum total and free T4 to decrease to the low levels observed in T3 inhibited rats. [1] |
| Alias | Anti-TSHR Antibody (K1-70) |
| Molecular Weight | 145.5 |
| Smiles | #N/A |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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