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KDU731

Name: KDU731
Brand: TargetMol
SKU: T15651
Price: 47 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T15651Cas No. 1610610-48-4

KDU731 is a promising drug candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety. KDU731is an orally active C. parvum inhibitor of PI4K (IC50: 25 nM). KDU731 blocks Cryptosporidium infection in vitro and in vivo.

KDU731

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Catalog No. T15651Cas No. 1610610-48-4

Pack Size	Price	Availability
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	KDU731 is a promising drug candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety. KDU731is an orally active C. parvum inhibitor of PI4K (IC50: 25 nM). KDU731 blocks Cryptosporidium infection in vitro and in vi
In vivo	KDU731 (p.o.; 5 mg/kg; every 12 hours for 7 days) is tolerated in all calves, and treated calves shed obviously fewer oocysts than vehicle-treated calves in their stool. KDU731 (p.o.; 7 or 10mg/kg; 16 days) has;effective activity against Cryptosporidium in immunocompromised IFN-γ KO mice and dramatically reduces oocyst shedding[2].

Chemical Properties

Molecular Weight	396.4
Formula	C₂₂H₁₆N₆O₂
Cas No.	1610610-48-4
Relative Density.	1.36 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 83.33 mg/mL (210.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5227 mL	12.6135 mL	25.2270 mL	126.1352 mL
5 mM	0.5045 mL	2.5227 mL	5.0454 mL	25.2270 mL
10 mM	0.2523 mL	1.2614 mL	2.5227 mL	12.6135 mL
20 mM	0.1261 mL	0.6307 mL	1.2614 mL	6.3068 mL
50 mM	0.0505 mL	0.2523 mL	0.5045 mL	2.5227 mL
100 mM	0.0252 mL	0.1261 mL	0.2523 mL	1.2614 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

KDU 731KDU731KDU-731