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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $3,920 | 10-14 weeks | |
50 mg | $5,180 | 10-14 weeks | |
100 mg | $7,300 | 10-14 weeks |
Description | KOS-1584 is a second-generation epothilone with potential antineoplastic activity. Epothilone KOS-1584 binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to first-generation epothilones, this agent exhibits greater safety and efficacy with an enhanced pharmaceutical profile, including enhanced water solubility and tumor penetration, and reduced CNS exposure. In addition, epothilone KOS-1584 is a poor substrate for the P-glycoprotein (P-gp) drug efflux pump. |
Molecular Weight | 489.67 |
Formula | C27H39NO5S |
Cas No. | 1032119-44-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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