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Kushenol X exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $2,289 | Backorder | |
1 mL x 10 mM (in DMSO) | $2,770 | Backorder |
Description | Kushenol X exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). |
Targets&IC50 | β-glucuronidase:2.07 μM (IC50), CES2A (human):3.05 μM (IC50) |
In vitro | Sixteen lavandulyl flavonoids were isolated and their structures were elucidated as kushenol H(1),kushenol K(2),kurarinol(3),kushenol Y(4),kushenol P(5),norkurarinone(6),kushenol I(7),kushenol N(8),(-)-kurarinone(9),Kushenol X(10),neokurarinol(11),kushenol C(12),sophoraflavanone G(13),leachianone A(14),kuraridine(15)and kushenol A(16). All isolated compounds exhibited inhibitory activity against SGLT2. Among them,the two main constituents of the active EtOAc fraction,(-)-kurarinone(9)and sophoraflavanone G(13)showed the most potential inhibitory activity against SGLT2with the IC50values of 2.24μmol/L and 1.45μmol/L,respectively. |
Molecular Weight | 440.49 |
Formula | C25H28O7 |
Cas No. | 254886-77-6 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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