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Kuwanon U
🥰Excellent
Catalog No. TN7715Cas No. 123702-95-4
Alias 4'-methoxykuwanon E
Kuwanon U (4'-methoxykuwanon E), a compound from Morus alba, is a cholinesterase inhibitor with antimicrobial activity, inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and exerts its inhibitory effect by preventing ATP binding in the cytoplasmic domain of SERCA1, which can be used in the study of diabetes mellitus and bacterial infections.
Kuwanon U
🥰Excellent
Catalog No. TN7715Alias 4'-methoxykuwanon ECas No. 123702-95-4
Kuwanon U (4'-methoxykuwanon E), a compound from Morus alba, is a cholinesterase inhibitor with antimicrobial activity, inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and exerts its inhibitory effect by preventing ATP binding in the cytoplasmic domain of SERCA1, which can be used in the study of diabetes mellitus and bacterial infections.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $679 | In Stock | |
| 5 mg | $1,430 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Kuwanon U (4'-methoxykuwanon E), a compound from Morus alba, is a cholinesterase inhibitor with antimicrobial activity, inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and exerts its inhibitory effect by preventing ATP binding in the cytoplasmic domain of SERCA1, which can be used in the study of diabetes mellitus and bacterial infections. |
| Targets&IC50 | Butyrylcholinesterase:9.59 µM (Ki), Butyrylcholinesterase:10.11 µM, Acetylcholinesterase:6.48 µM (Ki), Acetylcholinesterase:19.69 µM |
| In vitro | Kuwanon U is a potent cholinesterase inhibitor exhibiting inhibitory activity against acetylcholinesterase and butyrylcholinesterase with IC50 values of 19.69 µM and 10.11 µM and Ki values of 6.48 µM and 9.59 µM, respectively. [1] |
| Alias | 4'-methoxykuwanon E |
| Molecular Weight | 438.51 |
| Formula | C26H30O6 |
| Cas No. | 123702-95-4 |
| Smiles | O=C1C=2C(O[C@@H](C1)C3=CC(C/C=C(/CCC=C(C)C)\C)=C(OC)C=C3O)=CC(O)=CC2O |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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