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L-690330

Name: L-690330
Brand: TargetMol
SKU: T15685
Price: 38 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T15685Cas No. 142523-38-4

L-690330 is a competitive inositol monophosphatase inhibitor (Kis: 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase). L-690330 shows 10-fold more sensitive than a mouse and rat IMPase.

L-690330

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Catalog No. T15685Cas No. 142523-38-4

Pack Size	Price	Availability	Quantity
1 mL x 10 mM (in DMSO)	$143	7-10 days

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Product Introduction

Bioactivity

Description	L-690330 is a competitive inositol monophosphatase inhibitor (Kis: 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase). L-690330 shows 10-fold more sensitive than a mouse and rat IMPase.
Targets&IC50	IMPase (bovine recombinant):0.19 μM(ki), IMPase (bovine frontal cortex):0.42 μM, IMPase (human frontal cortex):0.30 μM(ki), IMPase (human recombinant):(ki)0.27 μM
In vitro	In HEK293 cells, L-690330 (50 μM; 1 hour) causes P-AMPK and autophagy and increases LC3-I/II and p-AMPK expression[2].
In vivo	Except for a reduction in time spent in light in the dark/light test, L-690330 (intracerebroventricular?injection; 0.1 μmol) shows no effects on their motor activity and coordination in the beam walking [3].

Chemical Properties

Molecular Weight	298.12
Formula	C₈H₁₂O₈P₂
Cas No.	142523-38-4
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 33.33 mg/mL (111.80 mM), Sonication is recommended.

DMSO: 25 mg/mL (83.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.3544 mL	16.7718 mL	33.5435 mL	167.7177 mL
5 mM	0.6709 mL	3.3544 mL	6.7087 mL	33.5435 mL
10 mM	0.3354 mL	1.6772 mL	3.3544 mL	16.7718 mL
20 mM	0.1677 mL	0.8386 mL	1.6772 mL	8.3859 mL
50 mM	0.0671 mL	0.3354 mL	0.6709 mL	3.3544 mL

H2O

	1mg	5mg	10mg	50mg
100 mM	0.0335 mL	0.1677 mL	0.3354 mL	1.6772 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

L 690330L-690330L690330