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Lapaquistat acetate

Name: Lapaquistat acetate
Brand: TargetMol
SKU: T15709
Price: 29 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T15709Cas No. 189060-13-7

Alias TAK-475

Lapaquistat acetate is a squalene synthase inhibitor. It also blocks the conversion of farnesyl diphosphate (FPP) to squalene. Lapaquistat acetate is used to Mevalonate Kinase Deficiency (MKD), it is effective at lowering low-density lipoprotein cholesterol, but it might cause liver damage.

Lapaquistat acetate

Catalog No. T15709Alias TAK-475Cas No. 189060-13-7

Pack Size	Price	Availability
25 mg	$3,819	10-14 weeks
50 mg	$5,328	10-14 weeks
100 mg	$6,929	10-14 weeks

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Product Introduction

Bioactivity

Description	Lapaquistat acetate is a squalene synthase inhibitor. It also blocks the conversion of farnesyl diphosphate (FPP) to squalene. Lapaquistat acetate is used to Mevalonate Kinase Deficiency (MKD), it is effective at lowering low-density lipoprotein cholester
Alias	TAK-475

Chemical Properties

Molecular Weight	645.14
Formula	C₃₃H₄₁ClN₂O₉
Cas No.	189060-13-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 46 mg/mL (71.30 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5501 mL	7.7503 mL	15.5005 mL	77.5026 mL
5 mM	0.3100 mL	1.5501 mL	3.1001 mL	15.5005 mL
10 mM	0.1550 mL	0.7750 mL	1.5501 mL	7.7503 mL
20 mM	0.0775 mL	0.3875 mL	0.7750 mL	3.8751 mL
50 mM	0.0310 mL	0.1550 mL	0.3100 mL	1.5501 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TAK 475TAK475Lapaquistat AcetateLapaquistat acetate