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Larsucosterol trimethylamine
🥰Excellent
Catalog No. T74147
Alias DV-928 trimethylamine, DUR-928 trimethylamine
Larsucosterol trimethylamine (DUR-928 trimethylamine) is a potent liver X receptor (LXR) antagonist that modulates endogenous epigenetics, reduces lipid accumulation in hepatocytes, attenuates lipopolysaccharide (LPS) and TNFα-induced inflammatory responses in macrophages, and alleviates LPS- and acetaminophen (ATMP)-induced multi-organ damage.
Larsucosterol trimethylamine
🥰Excellent
Purity: 97.0%
Catalog No. T74147Alias DV-928 trimethylamine, DUR-928 trimethylamine
Larsucosterol trimethylamine (DUR-928 trimethylamine) is a potent liver X receptor (LXR) antagonist that modulates endogenous epigenetics, reduces lipid accumulation in hepatocytes, attenuates lipopolysaccharide (LPS) and TNFα-induced inflammatory responses in macrophages, and alleviates LPS- and acetaminophen (ATMP)-induced multi-organ damage.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $192 | In Stock |
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Purity:97.0%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Larsucosterol trimethylamine (DUR-928 trimethylamine) is a potent liver X receptor (LXR) antagonist that modulates endogenous epigenetics, reduces lipid accumulation in hepatocytes, attenuates lipopolysaccharide (LPS) and TNFα-induced inflammatory responses in macrophages, and alleviates LPS- and acetaminophen (ATMP)-induced multi-organ damage. |
| In vitro | In a model of HG-induced MASLD in humanhepatocytes, Larsucosterol exhibits a specific inhibition of DNMTs. This results in the conversion of 5mCpG to CpG in the promoter regions of 1,074 genes within hepatocytes, leading to the upregulation of genes associated with key sig-naling pathways such as MAPK-ERK, calcium-AMPK, andtype II diabetes mellitus pathways. [1] |
| In vivo | In a mouse hepatectomy model, larsucosterol upregulates the expression of genes associated with cell replication, including Wt1 (Wilms’ tumor 1),PCNA (proliferating cell nuclear antigen), cMyc (myelocyto-matosis oncogene), cyclin A, FoxM1b (Forkhead Box M1b),and CDC25b (M-phase inducer phosphatase 2), whereas con-currently downregulating the expression of cell cycle arrestgene Chek2 (checkpoint kinase 2) and the apoptotic geneApaf1 (apoptotic peptidase activating factor 1). [1] |
| Alias | DV-928 trimethylamine, DUR-928 trimethylamine |
| Molecular Weight | 541.83 |
| Formula | C30H55NO5S |
| Smiles | C[C@@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]3[C@H]2CC=C4[C@]3(C)CC[C@H](OS(=O)(O)=O)C4)CCCC(C)(O)C.CN(C)C |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (39.27 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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